READY TO Utilise WHENEVER, WHEREVER

VALTOCO is designed to be administered past just about anyone. Information technology'south a practiced idea to share this information with care partners and loved ones.

If a person appears to be having a seizure, lay them either on their side or dorsum.

ane. Agree

VALTOCO® (diazepam nasal spray) instructions for use (step 1)

HOLD VALTOCO with your thumb on the lesser of the plunger and your get-go and middle fingers on either side of the nozzle.

Exercise Not test or prime; each device sprays only one time.

two. INSERT

VALTOCO® (diazepam nasal spray) instructions for use (step 2)

INSERT the tip of the nozzle into 1 nostril until your fingers, on either side of the nozzle, are against the bottom of the person'southward nose.

For nasal use only.

3. PRESS

VALTOCO® (diazepam nasal spray) instructions for use (step 3)

Press the lesser of the plunger firmly with your thumb to give VALTOCO.

Throw away nasal spray device(s) after utilize.

Instructions for Apply Videos

Await at the packaging of your VALTOCO to see which dosage you are prescribed. So spotter the appropriate video beneath on how you or your care partners tin administer the on-mitt rescue medication.

v mg or10 mg Dose

VALTOCO® (diazepam nasal spray) instructions for use video (5 mg and 10 mg doses)

15 mg ortwenty mg Dose

VALTOCO® (diazepam nasal spray) instructions for use video (15 mg and 20 mg doses)

VALTOCO® starter kit

Train With Confidence

Yous and your care partner(southward) tin exist prepared to apply VALTOCO with a kit that includes a training device, quick start guide, medication guide, and more.

Get the Demo Kit

Request training for VALTOCO®

Become virtual administration training from a VALTOCO nurse educator who provides instruction on how to use the on-mitt seizure rescue handling. Training is also available by telephone.

Asking Grooming

KNOW YOUR VALTOCO Dose

VALTOCO is bachelor in 4 treatment doses. Your healthcare provider will determine which dose is right for y'all using your age and weight.

Detect Your Recommended Dose

If you'd like to see a dosing chart, yous can get information technology here

more information on seizure treatment

You've got resources, including programs and downloadable tools, that can help you on your journeying to managing episodes of frequent seizure activity.

What Nosotros Have for You

IMPORTANT SAFETY Data,
INCLUDING BOXED Warning

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What is the nigh of import information I should know about VALTOCO?

  • VALTOCO is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other cardinal nervous system (CNS) depressants (including street drugs) tin cause astringent drowsiness, animate problems (respiratory low), coma, and expiry. Get emergency assistance right away if any of the following happens:
    • Shallow or slowed breathing
    • Breathing stops (which may lead to the centre stopping)
    • Excessive sleepiness (sedation)
  • Adventure of abuse, misuse, and addiction. In that location is a gamble for corruption, misuse, and addiction with benzodiazepines, including VALTOCO, which tin atomic number 82 to overdose and serious side effects including blackout and expiry.
    • Serious side furnishings accept happened in people who have abused or misused benzodiazepines, including diazepam (the active ingredient in VALTOCO). These serious side effects may also include delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. Call your healthcare provider or go to the nearest hospital emergency room right away if you get any of these serious side effects.
    • Utilise VALTOCO exactly equally your healthcare provider prescribed.
  • Physical dependence and withdrawal reactions. Benzodiazepines, including VALTOCO, can cause concrete dependence and withdrawal reactions, particularly if yous use VALTOCO daily. VALTOCO is not intended for daily apply.
  • VALTOCO tin can brand you sleepy or empty-headed and can wearisome your thinking and motor skills.
    • Do not drive, operate heavy machinery, or do other dangerous activities until you know how VALTOCO affects yous.
    • Do non drink alcohol or take opioid medicines that brand you sleepy or dizzy while taking VALTOCO until you lot talk to your healthcare provider. When taken with alcohol or medicines that can cause sleepiness or dizziness, VALTOCO may make your sleepiness or dizziness worse.
  • Like other antiepileptic drugs, VALTOCO may crusade suicidal thoughts or actions in a very small number of people, almost 1 in 500. Call a healthcare provider right abroad if you take whatsoever new or worsening suicidal thoughts or related symptoms, specially unusual changes in mood, behaviors, thoughts or feelings.

How can I watch for early symptoms of suicidal thoughts or deportment?

  • Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings.
  • Continue all follow-up visits with your healthcare provider as scheduled.
  • Call your healthcare provider between visits as needed, especially if you are worried almost symptoms. Suicidal thoughts or deportment can exist acquired by things other than medicines. If yous have suicidal thoughts or actions, your healthcare provider may check for other causes.

Do not use VALTOCO if you:

  • Are allergic to diazepam.
  • Have an eye problem called astute narrow-angle glaucoma.

What should I tell my doctor before taking VALTOCO?

Earlier using VALTOCO, tell your healthcare provider about all of your medical conditions, including if you:

  • Have asthma, emphysema, bronchitis, chronic obstructive pulmonary disease, or other animate problems.
  • Accept a history of alcohol or drug abuse.
  • Have a history of depression, mood issues, or suicidal thoughts or behavior.
  • Accept liver or kidney issues.
  • Are pregnant or plan to get pregnant. VALTOCO may harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. VALTOCO passes into your chest milk and may harm your infant. Talk to your healthcare provider most the best manner to feed your infant if you use VALTOCO.

Tell your healthcare provider nigh all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I utilise VALTOCO?

  • Read the Instructions for Use for detailed information near the right style to use VALTOCO.
  • Utilize VALTOCO exactly as prescribed by the healthcare provider.
  • Your healthcare provider will tell you:
    • What seizure clusters are
    • Exactly how much VALTOCO to give
    • When and how to give VALTOCO
    • What to practice after you lot give VALTOCO if the seizures do non stop or there is a modify in breathing, behavior, or condition that worries you lot
  • You should conduct VALTOCO with you in case yous need to control your seizure clusters.
  • VALTOCO is given in the nose (nasal) only.
  • Each VALTOCO only sprays 1 fourth dimension and cannot be reused. Do not examination or prime number the nasal spray before utilize.
  • Each dose of VALTOCO is provided in an individual pack. Use all of the medicine in 1 pack for a complete dose.

What should I do after I requite VALTOCO?

  • Stay with the person after yous requite VALTOCO and sentry them closely.
  • Make a notation of the time VALTOCO was given.
  • Call for emergency help if any of the following happen:
    • Seizure cluster behavior is different than other seizure clusters the person has had.
    • You are alarmed by how frequently the seizures happen, past how severe the seizure is, by how long the seizure lasts, or by the color or breathing of the person.
  • Throw away (discard) the used VALTOCO.

If needed, a second dose may be given at to the lowest degree 4 hours after the kickoff dose, using a new pack of VALTOCO. Practise not give more than 2 doses of VALTOCO to treat a seizure cluster.

A second dose should not be given if there is business near the person's breathing, they need help with their breathing, or take farthermost drowsiness.

Exercise non use VALTOCO for more 1 seizure cluster episode every 5 days. Do not employ VALTOCO for more than 5 seizure cluster episodes in 1 calendar month.

What are the near common side effects of VALTOCO?

The well-nigh mutual side effects of VALTOCO include:

  • Feeling sleepy or drowsy
  • Headache
  • Nose discomfort

These are non all of the possible side effects of VALTOCO. Telephone call your healthcare provider for medical advice well-nigh side furnishings. You lot may report side effects to Neurelis, Inc. at 1-866-696-3873 or to FDA at 1-800-FDA-1088.

Please run across full Prescribing Information and Medication Guide for additional important prophylactic data.

What is VALTOCO® (diazepam nasal spray)?

  • VALTOCO is a prescription medicine used for the brusque-term treatment of seizure clusters (also known as "episodes of frequent seizure action" or "acute repetitive seizures") in patients half-dozen years of historic period and older.
  • VALTOCO is a federally controlled substance (CIV) because it can exist abused or pb to dependence. Proceed VALTOCO in a safe place to forestall misuse and abuse. Selling or giving away VALTOCO may damage others and is against the law. Tell your healthcare provider if yous take driveling or been dependent on alcohol, prescription drugs, or street drugs.
  • It is not known if VALTOCO is safe and effective in children under 6 years of historic period.

Of import Safe Information

What is the most important information I should know about VALTOCO?

  • VALTOCO is a benzodiazepine medicine. Taking benzodiazepines with opioid medicines, alcohol, or other primal nervous system (CNS) depressants (including street drugs) tin can cause astringent drowsiness, breathing problems (respiratory depression), coma, and death. Get emergency help correct away if whatsoever of the following happens:
    • Shallow or slowed breathing
    • Breathing stops (which may lead to the centre stopping)
    • Excessive sleepiness (sedation)
  • Risk of abuse, misuse, and habit. There is a risk for corruption, misuse, and addiction with benzodiazepines, including VALTOCO, which can lead to overdose and serious side effects including blackout and death.
    • Serious side effects have happened in people who have abused or misused benzodiazepines, including diazepam (the active ingredient in VALTOCO). These serious side furnishings may besides include delirium, paranoia, suicidal thoughts or actions, seizures, and difficulty breathing. Call your healthcare provider or go to the nearest infirmary emergency room right away if you become whatever of these serious side effects.
    • Use VALTOCO exactly as your healthcare provider prescribed.
  • Physical dependence and withdrawal reactions. Benzodiazepines, including VALTOCO, tin cause physical dependence and withdrawal reactions, particularly if y'all use VALTOCO daily. VALTOCO is not intended for daily use.
  • VALTOCO can make y'all sleepy or light-headed and tin slow your thinking and motor skills.
    • Do not drive, operate heavy machinery, or do other dangerous activities until you know how VALTOCO affects y'all.
    • Practise not drink alcohol or take opioid medicines that make y'all sleepy or dizzy while taking VALTOCO until you lot talk to your healthcare provider. When taken with alcohol or medicines that can cause sleepiness or dizziness, VALTOCO may make your sleepiness or dizziness worse.
  • Like other antiepileptic drugs, VALTOCO may cause suicidal thoughts or actions in a very modest number of people, about ane in 500. Telephone call a healthcare provider right away if you have any new or worsening suicidal thoughts or related symptoms, especially unusual changes in mood, behaviors, thoughts or feelings.

How tin I watch for early on symptoms of suicidal thoughts or actions?

  • Pay attending to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings.
  • Continue all follow-up visits with your healthcare provider as scheduled.
  • Call your healthcare provider between visits as needed, especially if yous are worried nearly symptoms. Suicidal thoughts or deportment tin be caused by things other than medicines. If yous have suicidal thoughts or actions, your healthcare provider may check for other causes.

Practise non employ VALTOCO if you:

  • Are allergic to diazepam.
  • Have an center problem called astute narrow-bending glaucoma.

What should I tell my md before taking VALTOCO?

Before using VALTOCO, tell your healthcare provider near all of your medical conditions, including if you:

  • Have asthma, emphysema, bronchitis, chronic obstructive pulmonary illness, or other breathing issues.
  • Take a history of alcohol or drug corruption.
  • Have a history of depression, mood problems, or suicidal thoughts or behavior.
  • Have liver or kidney problems.
  • Are pregnant or program to get significant. VALTOCO may harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. VALTOCO passes into your chest milk and may harm your infant. Talk to your healthcare provider near the best way to feed your baby if yous utilize VALTOCO.

Tell your healthcare provider about all the medicines yous take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How should I employ VALTOCO?

  • Read the Instructions for Utilize for detailed data almost the right style to apply VALTOCO.
  • Use VALTOCO exactly equally prescribed by the healthcare provider.
  • Your healthcare provider will tell you:
    • What seizure clusters are
    • Exactly how much VALTOCO to give
    • When and how to give VALTOCO
    • What to practise later on you give VALTOCO if the seizures do not stop or there is a change in breathing, behavior, or status that worries y'all
  • Y'all should behave VALTOCO with y'all in example you demand to control your seizure clusters.
  • VALTOCO is given in the olfactory organ (nasal) but.
  • Each VALTOCO only sprays 1 time and cannot be reused. Practice not test or prime number the nasal spray before apply.
  • Each dose of VALTOCO is provided in an individual pack. Use all of the medicine in 1 pack for a complete dose.

What should I do subsequently I requite VALTOCO?

  • Stay with the person later on you give VALTOCO and watch them closely.
  • Make a note of the time VALTOCO was given.
  • Call for emergency help if any of the following happen:
    • Seizure cluster behavior is different than other seizure clusters the person has had.
    • You are alarmed past how frequently the seizures happen, by how severe the seizure is, by how long the seizure lasts, or by the color or breathing of the person.
  • Throw away (discard) the used VALTOCO.

If needed, a second dose may be given at least 4 hours later on the get-go dose, using a new pack of VALTOCO. Do non give more than two doses of VALTOCO to treat a seizure cluster.

A 2d dose should not be given if there is business about the person'due south breathing, they need help with their breathing, or have extreme drowsiness.

Do not use VALTOCO for more than 1 seizure cluster episode every 5 days. Exercise not apply VALTOCO for more than five seizure cluster episodes in 1 calendar month.

What are the well-nigh common side effects of VALTOCO?

The nigh mutual side effects of VALTOCO include:

  • Feeling sleepy or drowsy
  • Headache
  • Nose discomfort

These are non all of the possible side effects of VALTOCO. Call your healthcare provider for medical advice about side furnishings. You may report side effects to Neurelis, Inc. at i-866-696-3873 or to FDA at 1-800-FDA-1088.

Delight meet full Prescribing Information and Medication Guide for additional important rubber information.